Featured
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Matters Arising |
Reply to: Beta human papillomaviruses and skin cancer
- John D. Strickley
- , Jonathan L. Messerschmidt
- & Shadmehr Demehri
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Article |
Defining HPV-specific B cell responses in patients with head and neck cancer
Detailed analyses of B cells in the tumour microenvironment of human papilloma virus (HPV)-linked head and neck cancers reveal strong humoral immune responses to HPV antigens and the secretion of HPV-specific antibodies in situ.
- Andreas Wieland
- , Mihir R. Patel
- & Rafi Ahmed
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Article |
Immunity to commensal papillomaviruses protects against skin cancer
A mouse model of papillomavirus infection reveals that skin colonization with commensal papillomaviruses protects the immunocompetent host against chemical- and UV-induced skin cancer through CD8+ T cell immunity.
- John D. Strickley
- , Jonathan L. Messerschmidt
- & Shadmehr Demehri
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Letter |
Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53
WebStructural details of how oncogenic human papilloma viruses induce cancer by targeting the tumour suppressor p53 for ubiquitin-mediated degradation.
- Denise Martinez-Zapien
- , Francesc Xavier Ruiz
- & Katia Zanier
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Outlook |
HPV: The global burden
Human papillomavirus (HPV) has become synonymous with cervical cancer, but its actual footprint is much bigger, by James Mitchell Crow.
- James Mitchell Crow
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Outlook |
Clinical approval: Trials of an anticancer jab
Two vaccines seem to be so effective in preventing HPV infection that mass vaccination has been introduced for girls. But will long-term studies show falls in cervical cancer?
- Julie Clayton
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Outlook |
Pathology: Three questions
Linking specific types of HPV with cervical cancer and developing effective vaccines against should be celebrated. But there are gaps in our understanding of these viruses and how they cause disease.
- Laura Vargas-Parada
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Outlook |
Q&A: On the case
A Nobel prizewinner for pinning cervical cancer on human papillomavirus, Harald zur Hausen still investigates viruses. Nature Outlook talks to the medical doctor–turned–virologist about other possible culprits.
- Harald zur Hausen
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Outlook |
Vaccination: A durable design
Vaccines on the market aren't practical for the developing world — where cervical cancer hits hardest — but researchers are trying to make ones that are.
- Katharine Sanderson
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Outlook |
Perspective: Vaccinate boys too
HPV-associated cancers in men are on the rise. By not vaccinating boys we are failing to gain maximum health benefit, argues Margaret Stanley.
- Margaret Stanley
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Outlook |
Public health: Prevention comes of age
Sub-Saharan countries lag behind in screening and treatment for human papillomavirus. But national efforts and the introduction of low-tech methods could change that.
- Michael Eisenstein
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Obituary |
Renato Dulbecco (1914–2012)
Molecular biologist who proved that virus-derived genes can trigger cancer.
- Inder M. Verma
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Research Highlights |
Cell biology: Communication key to cancer virus