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| Open AccessSmall-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogens
- Michael Greenberg
- , David Kuo
- & Menachem Shoham
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| Open AccessPotent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction
- Edward Y. S. Lin
- , Laura F. Silvian
- & Kevin M. Guckian
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| Open AccessSmall molecule activator of Nm23/NDPK as an inhibitor of metastasis
- Jae-Jin Lee
- , Hwang Suk Kim
- & Kong-Joo Lee
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| Open AccessRepurposing drugs to target the malaria parasite unfolding protein response
- Yun Chen
- , Claribel Murillo-Solano
- & Juan C. Pizarro
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| Open AccessQuality control of the traditional Chinese medicine Ruyi jinhuang powder based on high-throughput sequencing and real-time PCR
- Qiang Li
- , Ying Sun
- & Liran Xu
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| Open AccessVirulence-inhibitory activity of the degradation product 3-hydroxybutyrate explains the protective effect of poly-β-hydroxybutyrate against the major aquaculture pathogen Vibrio campbellii
- Tom Defoirdt
- , Nguyen Thi Mai Anh
- & Peter De Schryver
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| Open AccessAllosteric modulation of the farnesoid X receptor by a small molecule
- Matthias Gabler
- , Jan Kramer
- & Daniel Merk
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| Open AccessRUNX1 positively regulates the ErbB2/HER2 signaling pathway through modulating SOS1 expression in gastric cancer cells
- Yoshihide Mitsuda
- , Ken Morita
- & Yasuhiko Kamikubo
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| Open AccessComputational repositioning and preclinical validation of mifepristone for human vestibular schwannoma
- Jessica E. Sagers
- , Adam S. Brown
- & Konstantina M. Stankovic
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| Open AccessSites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange
- Laura J. Byrnes
- , Yingrong Xu
- & Graham M. West
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| Open AccessCardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction
- Sini M. Kinnunen
- , Marja Tölli
- & Heikki Ruskoaho
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| Open AccessDown-regulation of GADD45A enhances chemosensitivity in melanoma
- Jia Liu
- , Guoqiang Jiang
- & Weiling Li
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| Open AccessChimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors
- Oleg G. Chepurny
- , Ron L. Bonaccorso
- & George G. Holz
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| Open AccessAnti-fibrotic Effects of CXCR4-Targeting i-body AD-114 in Preclinical Models of Pulmonary Fibrosis
- K. Griffiths
- , D. M. Habiel
- & M. Foley
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| Open AccessThe Mechanisms of Bushen-Yizhi Formula as a Therapeutic Agent against Alzheimer’s Disease
- Haobin Cai
- , Yunxia Luo
- & Jun Xu
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| Open AccessDYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives
- Fernanda Neumann
- , Stéphanie Gourdain
- & Robert H. Dodd
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| Open AccessEffect of tetramethylpyrazine on tibial dyschondroplasia incidence, tibial angiogenesis, performance and characteristics via HIF-1α/VEGF signaling pathway in chickens
- Khalid Mehmood
- , Hui Zhang
- & Jiakui Li
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| Open AccessDepletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine
- Mao-Hua Cai
- , Xiao-Gang Xu
- & Yue-Xing Tu
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| Open AccessTargeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells
- Amila K. Nanayakkara
- , Courtney A. Follit
- & John G. Wise
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| Open AccessUncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation
- Li Gao
- , Ke-xin Wang
- & Guan-hua Du
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| Open AccessDevelopment of a PET radioligand for potassium channels to image CNS demyelination
- Pedro Brugarolas
- , Jorge E. Sánchez-Rodríguez
- & Brian Popko
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| Open AccessConnexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases
- Wei Li
- , Guoqiang Bao
- & Haichao Wang
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| Open AccessInhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways
- Heeyoon Jeong
- , Ara Koh
- & Sung Ho Ryu
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| Open AccessSmall molecules related to adrenomedullin reduce tumor burden in a mouse model of colitis-associated colon cancer
- Laura Ochoa-Callejero
- , Josune García-Sanmartín
- & Alfredo Martínez
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| Open AccessDesign and synthesis of 5-aryl-4-(4-arylpiperazine-1-carbonyl)-2H-1,2,3-triazole derivatives as colchicine binding site inhibitors
- Yue Wu
- , Dongjie Feng
- & Weige Zhang
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| Open AccessRepurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis
- Sergey A. Shiryaev
- , Pinar Mesci
- & Alexey V. Terskikh
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| Open AccessIn vivo near-infrared imaging of ErbB2 expressing breast tumors with dual-axes confocal endomicroscopy using a targeted peptide
- Zhenghong Gao
- , Gaoming Li
- & Thomas D. Wang
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| Open Access4-Hydroxybenzaldehyde accelerates acute wound healing through activation of focal adhesion signalling in keratinocytes
- Chan Woo Kang
- , Ye Eon Han
- & Eun Jig Lee
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| Open AccessA formulation of pancreatic pro-enzymes provides potent anti-tumour efficacy: a pilot study focused on pancreatic and ovarian cancer
- Macarena Perán
- , Elena López-Ruiz
- & Julian Kenyon
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| Open AccessConformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
- María A. Urbaneja
- , Lars Skjærven
- & Sonia Bañuelos
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| Open AccessRare occurrence of inflammatory bowel disease in a cohort of Han Chinese ankylosing spondylitis patients- a single institute study
- Chrong-Reen Wang
- , Chia-Tse Weng
- & Ming-Fei Liu
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| Open AccessCETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens
- Tsuyoshi Ishii
- , Takuro Okai
- & Tomohiro Kawamoto
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| Open AccessStructure-Activity Relationship Studies of β-Lactam-azide Analogues as Orally Active Antitumor Agents Targeting the Tubulin Colchicine Site
- Dong-Jun Fu
- , Ling Fu
- & Hong-Min Liu
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| Open AccessAstragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway
- Shih-Yu Lee
- , Wei-Cheng Tsai
- & Tsu-Chung Chang
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| Open AccessNovel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes
- Emir Salas-Sarduy
- , Lionel Urán Landaburu
- & Vanina Eder Alvarez
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| Open AccessStructural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE
- Shulin Hou
- , Tingting Xu
- & Jinsong Liu
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| Open AccessPromotion effect of extracts from plastrum testudinis on alendronate against glucocorticoid-induced osteoporosis in rat spine
- Hui Ren
- , Gengyang Shen
- & Xiaobing Jiang
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| Open AccessTylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication
- Ying Wang
- , Sangwon Lee
- & Yung-Chi Cheng
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| Open AccessInhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface
- Katherine A. Abrahams
- , Jonathan A. G. Cox
- & Gurdyal S. Besra
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| Open AccessStigmasterol prevents glucolipotoxicity induced defects in glucose-stimulated insulin secretion
- Meliza G. Ward
- , Ge Li
- & Mingming Hao
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| Open AccessStructural basis for therapeutic inhibition of influenza A polymerase PB2 subunit
- Xiaolei Ma
- , Lili Xie
- & Vincent H. J. Leonard
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| Open AccessMEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis
- Rachel L. Edwards
- , Robert C. Brothers
- & Audrey R. Odom John
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| Open AccessIdentification of Novel Non-secosteroidal Vitamin D Receptor Agonists with Potent Cardioprotective Effects and devoid of Hypercalcemia
- Santosh A. Khedkar
- , Mohammed A. Samad
- & Peter M. Kang
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| Open AccessTargeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells
- Akihiro Fujikawa
- , Hajime Sugawara
- & Masaharu Noda
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| Open AccessInhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis
- Alexandre Henriques
- , Mylene Huebecker
- & Jean-Philippe Loeffler
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| Open AccessA novel protein kinase inhibitor IMB-YH-8 with anti-tuberculosis activity
- Jian Xu
- , Ju-xian Wang
- & Li-yan Yu
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| Open AccessMap3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis
- Ángela Sánchez
- , Carlos Relaño
- & Susana Alemany
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| Open AccessThe Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages
- Karim Chebli
- , Laura Papon
- & Jamal Tazi
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| Open AccessKnockout of the peroxiredoxin 5 homologue PFAOP does not affect the artemisinin susceptibility of Plasmodium falciparum
- Carine F. Djuika
- , Verena Staudacher
- & Marcel Deponte