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| Open AccessDP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time
- Michael Kurz
- , Michaela Ulrich
- & Moritz Bünemann
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| Open AccessKv3.4 regulates cell migration and invasion through TGF-β-induced epithelial–mesenchymal transition in A549 cells
- Hun Ju Sim
- , Mi Ri Kim
- & So Yeong Lee
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| Open AccessAdenosine A1 receptors of the medullary solitary tract arbitrate the nicotine counteraction of neuroinflammation and cardiovascular dysfunction in septic rats
- Amany E. El-Naggar
- , Mai M. Helmy
- & Mahmoud M. El-Mas
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| Open AccessA critical re-evaluation of the slope factor of the operational model of agonism: When to exponentiate operational efficacy
- Alena Randáková
- , Dominik Nelic
- & Jan Jakubík
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| Open AccessRecovery of the histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection
- Ayami Watanabe
- , Ami Nakajima
- & Mitsunori Shiroishi
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| Open AccessKinin B1 and B2 receptors mediate cancer pain associated with both the tumor and oncology therapy using aromatase inhibitors
- Indiara Brusco
- , Gabriela Becker
- & Sara Marchesan Oliveira
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| Open AccessHuman osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling
- Arundhasa Chandrabalan
- , Andrew Firth
- & Rithwik Ramachandran
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| Open AccessEicosapentaenoic acid (EPA)-induced inhibitory effects on porcine coronary and cerebral arteries involve inhibition of prostanoid TP receptors
- Kento Yoshioka
- , Keisuke Obara
- & Yoshio Tanaka
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| Open AccessDiscovery of a novel class of benzimidazoles as highly effective agonists of bone morphogenetic protein (BMP) receptor signaling
- Sheyda Najafi
- , Leonard Barasa
- & Jeanette C. Perron
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| Open AccessIn vitro study on efficacy of PHELA, an African traditional drug against SARS-CoV-2
- M. G. Matsabisa
- , K. Alexandre
- & H. P. Chabalala
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| Open AccessInvestigating the ligand agonism and antagonism at the D2long receptor by dynamic mass redistribution
- Lisa Forster
- & Steffen Pockes
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| Open AccessDeprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
- Artur Wnorowski
- , Danuta Dudzik
- & Irving W. Wainer
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| Open AccessComprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay
- Alexander Medvedev
- , Matt Moeser
- & Sergei S. Makarov
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| Open AccessPlatelet-activating factor (PAF) strongly enhances contractile mechanical activities in guinea pig and mouse urinary bladder
- Ge Liu
- , Mizuki Kaneko
- & Yoshio Tanaka
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| Open AccessA multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins
- Rodrigo Aguayo-Ortiz
- , Jeffery Creech
- & L. Michel Espinoza-Fonseca
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| Open AccessIdentification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition
- Xuesong Wang
- , Willem Jespers
- & Hugo Gutiérrez-de-Terán
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| Open AccessConserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2
- Abanoub A. Gad
- , Pedram Azimzadeh
- & Nariman Balenga
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| Open AccessLabel-free high-throughput screening assay for the identification of norepinephrine transporter (NET/SLC6A2) inhibitors
- Hubert J. Sijben
- , Wieke M. van Oostveen
- & Laura H. Heitman
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| Open AccessThe combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice
- Hamideh Bashiri
- , Danielle J. Houwing
- & Ali-Akbar Salari
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| Open AccessNew phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling
- Anika Mann
- , Alastair C. Keen
- & J. Robert Lane
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| Open AccessPentagalloyl glucose inhibits TNF‐α‐activated CXCL1/GRO-α expression and induces apoptosis‐related genes in triple-negative breast cancer cells
- Patricia Mendonca
- , Sumaih Alghamdi
- & Karam F. A. Soliman
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| Open AccessAltered functional properties of the codling moth Orco mutagenized in the intracellular loop-3
- Yuriy V. Bobkov
- , William B. Walker III
- & Alberto Maria Cattaneo
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| Open AccessEnhancement of parvalbumin interneuron-mediated neurotransmission in the retrosplenial cortex of adolescent mice following third trimester-equivalent ethanol exposure
- Clark W. Bird
- , Glenna J. Chavez
- & C. Fernando Valenzuela
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| Open AccessA study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery
- Hubert J. Sijben
- , Julie J. E. van den Berg
- & Laura H. Heitman
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| Open AccessDevelopment of phenotypic assays for identifying novel blockers of L-type calcium channels in neurons
- Rebecca Hagan
- , Elizabeth Rex
- & Yi Liu
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| Open AccessA capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability
- Magdalena Nikolaeva-Koleva
- , Laura Butron
- & Antonio Ferrer-Montiel
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| Open AccessPharmacological characterisation of novel adenosine A3 receptor antagonists
- Kerry Barkan
- , Panagiotis Lagarias
- & Graham Ladds
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| Open AccessIn vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
- Ayat Zagzoog
- , Kawthar A. Mohamed
- & Robert B. Laprairie
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| Open AccessDevelopment and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer
- Viswas Raja Solomon
- , Elahe Alizadeh
- & Humphrey Fonge
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| Open AccessDissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells
- Thor C. Møller
- , Mie F. Pedersen
- & Hans Bräuner-Osborne
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| Open AccessDopamine D1 receptor signalling in dyskinetic Parkinsonian rats revealed by fiber photometry using FRET-based biosensors
- Jace Jones-Tabah
- , Hanan Mohammad
- & Terence E. Hébert
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| Open AccessThe operational model of allosteric modulation of pharmacological agonism
- Jan Jakubík
- , Alena Randáková
- & Vladimír Doležal
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Article
| Open AccessOral Phyto-thymol ameliorates the stress induced IBS symptoms
- Selvaraj Subramaniyam
- , Shuyou Yang
- & Sanjib Bhattacharyya
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| Open AccessEpigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader–Willi Syndrome
- David Reiner
- , Ludwig Seifert
- & Holger Stark
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| Open AccessA single unified model for fitting simple to complex receptor response data
- Peter Buchwald
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| Open AccessLevodopa inhibits the development of lens-induced myopia in chicks
- Kate Thomson
- , Ian Morgan
- & Regan Ashby
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| Open AccessDiscovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABAA receptors
- Christina Birkedahl Falk-Petersen
- , Tsonko M. Tsonkov
- & Petrine Wellendorph
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| Open AccessSimple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression
- James M. Brimson
- , Kiran K. Akula
- & Stephen T. Safrany
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| Open AccessVasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors
- Vanessa Vezzi
- , Caterina Ambrosio
- & Susanna Cotecchia
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| Open AccessSignal profiling of the β1AR reveals coupling to novel signalling pathways and distinct phenotypic responses mediated by β1AR and β2AR
- Viktoriya Lukasheva
- , Dominic Devost
- & Terence E. Hébert
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| Open AccessSoluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy
- Lucia Scarabel
- , Marica Garziera
- & Silvano Geremia
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| Open AccessDrosophila taste neurons as an agonist-screening platform for P2X receptors
- Leanne Grimes
- , Julia Griffiths
- & Wynand van der Goes van Naters
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| Open AccessA Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain
- Louis Hilfiger
- , Qian Zhao
- & Alexandre Charlet
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| Open AccessStructure-based development of caged dopamine D2/D3 receptor antagonists
- Marie Gienger
- , Harald Hübner
- & Peter Gmeiner
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| Open AccessThe Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis
- Kanako Miyano
- , Moeko Eto
- & Yasuhito Uezono
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| Open AccessNafamostat and sepimostat identified as novel neuroprotective agents via NR2B N-methyl-D-aspartate receptor antagonism using a rat retinal excitotoxicity model
- Masahiro Fuwa
- , Masaaki Kageyama
- & Kei Tashiro
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| Open AccessI8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor
- Leopold Duerrauer
- , Edin Muratspahić
- & Christian W. Gruber
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| Open AccessMebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma
- Nancy S. Younis
- , Amal M. H. Ghanim
- & Sameh Saber