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Letter |
Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents
CRISPR–Cas9 genome editing is used to correct a dominant-negative mutation in a mouse model of inherited deafness, resulting in improvements in cochlear function and hearing.
- Xue Gao
- , Yong Tao
- & David R. Liu
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Article |
De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure
The structure of the bacterial toxin BinAB, which is used to combat mosquito-borne diseases, reveals pH-sensitive switches and carbohydrate-binding modules that may contribute to the larvicidal function of the toxin.
- Jacques-Philippe Colletier
- , Michael R. Sawaya
- & David S. Eisenberg