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| Open AccessDevelopment of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state
- Yasuhiro Nakano
- , Eiko Saijou
- & Taketomo Kido
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| Open AccessCharacterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array
- Minami Hiranuma
- , Yuichi Okuda
- & Tomohisa Watanabe
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| Open AccessRestoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates
- Hsiang-Yu Chang
- & I-Fan Wang
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| Open AccessA scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds
- Kevin Lin
- , Ya-Chu Chang
- & Chad L. Myers
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| Open AccessBezafibrate attenuates immobilization-induced muscle atrophy in mice
- Satoshi Nakamura
- , Yuiko Sato
- & Takeshi Miyamoto
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| Open AccessTransfer learning for versatile and training free high content screening analyses
- Maxime Corbe
- , Gaëlle Boncompain
- & Auguste Genovesio
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| Open AccessArtificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds
- Anna Jagielska
- , Kristin Radzwill
- & Krystyn J. Van Vliet
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| Open AccessThe anticancer and antibacterial potential of bioactive secondary metabolites derived From bacterial endophytes in association with Artemisia absinthium
- Mohammad Sadegh Damavandi
- , Hasan Shojaei
- & Bahram Nasr Esfahani
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| Open AccessIdentification of side effects of COVID-19 drug candidates on embryogenesis using an integrated zebrafish screening platform
- Alexander Ernst
- , Indre Piragyte
- & Nadia Mercader
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| Open AccessNew drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
- Ashish Kumar Sharma
- , Shivam Singh
- & Arun Garg
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| Open Access1′-O-methyl-averantin isolated from the endolichenic fungus Jackrogersella sp. EL001672 suppresses colorectal cancer stemness via sonic Hedgehog and Notch signaling
- Mücahit Varlı
- , Eun-Young Lee
- & Hangun Kim
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| Open AccessSuccinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning
- Sarah Piel
- , Joanna I. Janowska
- & Todd J. Kilbaugh
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| Open AccessDYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
- Bangfu Zhu
- , Tom Parsons
- & James J. L. Hodge
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| Open AccessNovel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening
- Anuradha Kumar
- , Somsundaram Chettiar
- & Tanya Parish
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| Open AccessVerteporfin ameliorates fibrotic aspects of Dupuytren’s disease nodular fibroblasts irrespective the activation state of the cells
- Nataly Puerta Cavanzo
- , Sophie A. Riesmeijer
- & Ruud A. Bank
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| Open AccessEfficacy of 0.01% low dose atropine and its correlation with various factors in myopia control in the Indian population
- Shweta Chaurasia
- , Seema Negi
- & Mangat Ram Dogra
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| Open AccessA combination screening to identify enhancers of para-aminosalicylic acid against Mycobacterium tuberculosis
- Jinyeong Heo
- , Dahae Koh
- & Vincent Delorme
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| Open AccessNU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone
- Barış Genç
- , Mukesh Gautam
- & P. Hande Ozdinler
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| Open AccessMetabolites of soil microorganisms modulate amyloid β production in Alzheimer’s neurons
- Takayuki Kondo
- , Tsuyoshi Yamamoto
- & Haruhisa Inoue
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| Open AccessA cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors
- Julie K. Fierle
- , Johan Abram-Saliba
- & Steven M. Dunn
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| Open AccessThe transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design
- Isabelle Q. Phan
- , Christopher A. Rice
- & Peter J. Myler
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| Open AccessDevelopment of CIDEA reporter mouse model and its application for screening thermogenic drugs
- Yeonho Son
- , Cheoljun Choi
- & Yun-Hee Lee
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| Open AccessMitochondria-affecting small molecules ameliorate proteostasis defects associated with neurodegenerative diseases
- Elissa Tjahjono
- , Jingqi Pei
- & Natalia V. Kirienko
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| Open AccessDrug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa
- Logan Ganzen
- , Mee Jung Ko
- & Yuk Fai Leung
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| Open AccessInhibitory effects of aprotinin on influenza A and B viruses in vitro and in vivo
- Eun-Jung Song
- , Erica Españo
- & Jeong-Ki Kim
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| Open AccessVortioxetine ameliorates anhedonic-like behaviour and promotes strategic cognitive performance in a rodent touchscreen task
- Lena-Sophie Martis
- , Kristoffer Højgaard
- & Ove Wiborg
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| Open AccessSmall compounds mimicking the adhesion molecule L1 improve recovery in a zebrafish demyelination model
- Suhyun Kim
- , Dong-Won Lee
- & Hae-Chul Park
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| Open AccessChemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites
- Dorjbal Dorjsuren
- , Richard T. Eastman
- & David A. Fidock
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| Open AccessA high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics
- Anthony D. Verderosa
- , Rabeb Dhouib
- & Makrina Totsika
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| Open AccessIntegrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening
- Ibrahim Boussaad
- , Gérald Cruciani
- & Rejko Krüger
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| Open AccessEffects of different combined regimens of cisplatin, metformin, and quercetin on nasopharyngeal carcinoma cells and subcutaneous xenografts
- Zhongwei Chen
- , Zhen Zeng
- & Xuan Hong
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| Open AccessDevelopment of phenotypic assays for identifying novel blockers of L-type calcium channels in neurons
- Rebecca Hagan
- , Elizabeth Rex
- & Yi Liu
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| Open AccessIdentification of the hypertension drug niflumic acid as a glycine receptor inhibitor
- Daishi Ito
- , Yoshinori Kawazoe
- & Hiromi Hirata
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| Open AccessTales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines
- Michael J. Cox
- , Steffen Jaensch
- & Hinrich W. H. Göhlmann
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| Open AccessA novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
- Mailis Maes
- , Zoe A. Dyson
- & Josefin Bartholdson Scott
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| Open AccessA robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans
- Julia Zwirchmayr
- , Benjamin Kirchweger
- & Judith M. Rollinger
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| Open AccessReal-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib
- Amy M. Buckley
- , Margaret R. Dunne
- & Jacintha O’Sullivan
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| Open AccessProlongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans
- Dagmar Pretsch
- , Judith Maria Rollinger
- & Alexander Pretsch
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| Open AccessAlkyl-carbon chain length of two distinct compounds and derivatives are key determinants of their anti-Acanthamoeba activities
- Ronnie Mooney
- , Mariana Masala
- & Roderick Adeyinka Malcolm Williams
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| Open AccessA multi-batch design to deliver robust estimates of efficacy and reduce animal use – a syngeneic tumour case study
- Natasha A. Karp
- , Zena Wilson
- & Elizabeth Hardaker
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| Open AccessInhibitors of Na+/K+ ATPase exhibit antitumor effects on multicellular tumor spheroids of hepatocellular carcinoma
- Yeonhwa Song
- , Su-Yeon Lee
- & Haeng Ran Seo
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| Open AccessA high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells
- Rosita R. Asawa
- , Carina Danchik
- & Natalia J. Martinez
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| Open AccessStreptonigrin at low concentration promotes heterochromatin formation
- Andre C. Loyola
- , Kevin Dao
- & Willis X. Li
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| Open AccessFisetin protects against cardiac cell death through reduction of ROS production and caspases activity
- Sophie Rodius
- , Niek de Klein
- & Francisco Azuaje
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| Open AccessFluopack screening platform for unbiased cellular phenotype profiling
- Zhao B. Kang
- , Ioannis Moutsatsos
- & Christophe Antczak
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| Open AccessPotent inhibition of HIV replication in primary human cells by novel synthetic polyketides inspired by Aureothin
- Alexander Herrmann
- , Manfred Roesner
- & Ruth Brack-Werner
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| Open AccessStructure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens
- Edgar Ferrer-González
- , Junso Fujita
- & Daniel S. Pilch
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| Open AccessAssessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons
- Pei-Chun Wu
- , Ming-Ji Fann
- & Yu-Hui Wong
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| Open AccessIdentification of a Phenylthiazole Small Molecule with Dual Antifungal and Antibiofilm Activity Against Candida albicans and Candida auris
- Haroon Mohammad
- , Hassan E. Eldesouky
- & Mohamed N. Seleem