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| Open AccessA humanized anti-DLL4 antibody promotes dysfunctional angiogenesis and inhibits breast tumor growth
- Xuelian Jia
- , Wenyi Wang
- & Min Wu
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| Open AccessModeling and fitting protein-protein complexes to predict change of binding energy
- Daniel F.A.R. Dourado
- & Samuel Coulbourn Flores
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| Open AccessRational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability
- Carlo Camilloni
- , Benedetta Maria Sala
- & Stefano Ricagno
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| Open Access3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors
- Yajing Fang
- , Yulin Lu
- & Xiaoyun Xu
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| Open AccessAccurate Determination of Conformational Transitions in Oligomeric Membrane Proteins
- Máximo Sanz-Hernández
- , Vitaly V. Vostrikov
- & Alfonso De Simone
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| Open AccessInsight into determinants of substrate binding and transport in a multidrug efflux protein
- Kamela O. Alegre
- , Stephanie Paul
- & Christopher J. Law
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| Open AccessUsing mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development
- Chia-Lin Liu
- , Hui-Chen Hung
- & Ming-Hon Hou
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| Open AccessConformational plasticity of RepB, the replication initiator protein of promiscuous streptococcal plasmid pMV158
- D. Roeland Boer
- , José Angel Ruiz-Masó
- & Miquel Coll
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| Open AccessStructure of ring-shaped Aβ42 oligomers determined by conformational selection
- Linh Tran
- , Nathalie Basdevant
- & Tâp Ha-Duong
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| Open AccessEffective pore size and radius of capture for K+ ions in K-channels
- Hans Moldenhauer
- , Ignacio Díaz-Franulic
- & David Naranjo
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| Open AccessFunctional mutagenesis screens reveal the ‘cap structure’ formation in disulfide-bridge free TASK channels
- Matthias Goldstein
- , Susanne Rinné
- & Niels Decher
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| Open AccessCharacterizing the Conformational Landscape of Flavivirus Fusion Peptides via Simulation and Experiment
- Jan K. Marzinek
- , Rajamani Lakshminarayanan
- & Peter J. Bond
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Article
| Open AccessBenchmarking Deep Networks for Predicting Residue-Specific Quality of Individual Protein Models in CASP11
- Tong Liu
- , Yiheng Wang
- & Zheng Wang
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Article
| Open AccessEnergetics of Endotoxin Recognition in the Toll-Like Receptor 4 Innate Immune Response
- Teresa Paramo
- , Susana M. Tomasio
- & Peter J. Bond
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Article
| Open AccessConservation and Role of Electrostatics in Thymidylate Synthase
- Divita Garg
- , Stephane Skouloubris
- & Rebecca C. Wade
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Article
| Open AccessMechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase
- O. Lidor
- , A. Al-Quntar
- & D. Steinberg
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| Open AccessDeciphering Supramolecular Structures with Protein-Protein Interaction Network Modeling
- Toshiyuki Tsuji
- , Takao Yoda
- & Tsuyoshi Shirai
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| Open AccessAβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function
- Christian Barucker
- , Heiko J. Bittner
- & Gerhard Multhaup
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| Open AccessAssociation analyses of large-scale glycan microarray data reveal novel host-specific substructures in influenza A virus binding glycans
- Nan Zhao
- , Brigitte E. Martin
- & Xiu-Feng Wan
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| Open AccessSelector function of MHC I molecules is determined by protein plasticity
- Alistair Bailey
- , Neil Dalchau
- & Tim Elliott
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| Open AccessKinetic characterization of trans-proteolytic activity of Chikungunya virus capsid protease and development of a FRET-based HTS assay
- Megha Aggarwal
- , Rajesh Sharma
- & Shailly Tomar
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| Open AccessStructural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation
- Christine B. Karim
- , L. Michel Espinoza-Fonseca
- & Ameeta Kelekar
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| Open AccessA structural dissection of large protein-protein crystal packing contacts
- Jiesi Luo
- , Zhongyu Liu
- & Menglong Li
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| Open AccessFlexibility and extracellular opening determine the interaction between ligands and insect sulfakinin receptors
- Na Yu
- , Moises João Zotti
- & Guy Smagghe
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| Open AccessHomology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification
- Yi-Yu Ke
- , Vivek Kumar Singh
- & Hsing-Pang Hsieh
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| Open AccessStructural and Physical Basis for Anti-IgE Therapy
- Jon D. Wright
- , Hsing-Mao Chu
- & Carmay Lim
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| Open AccessImproving prediction of secondary structure, local backbone angles and solvent accessible surface area of proteins by iterative deep learning
- Rhys Heffernan
- , Kuldip Paliwal
- & Yaoqi Zhou
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Article
| Open AccessThe actions of neurotensin in rat bladder detrusor contractility
- Xingyou Dong
- , Xinyu Bai
- & Longkun Li
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Article
| Open AccessUnraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex
- Thomas Bourquard
- , Flavie Landomiel
- & Anne Poupon
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| Open AccessDeveloping the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications
- Daniel M. Czajkowsky
- , Jan Terje Andersen
- & Richard J. Pleass
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| Open AccessHidden relationships between metalloproteins unveiled by structural comparison of their metal sites
- Yana Valasatava
- , Claudia Andreini
- & Antonio Rosato
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| Open AccessThe Glycan Role in the Glycopeptide Immunogenicity Revealed by Atomistic Simulations and Spectroscopic Experiments on the Multiple Sclerosis Biomarker CSF114(Glc)
- Agostino Bruno
- , Mario Scrima
- & Vittorio Limongelli
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| Open AccessRational stabilization of complex proteins: a divide and combine approach
- Emilio Lamazares
- , Isabel Clemente
- & Javier Sancho
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| Open AccessEquilibrated Atomic Models of Outward-Facing P-glycoprotein and Effect of ATP Binding on Structural Dynamics
- Lurong Pan
- & Stephen G. Aller
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| Open AccessPIP2-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6
- Marina A. Kasimova
- , Mark A. Zaydman
- & Mounir Tarek
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| Open AccessGlobal connectivity of hub residues in Oncoprotein structures encodes genetic factors dictating personalized drug response to targeted Cancer therapy
- Venky Soundararajan
- & Murali Aravamudan
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| Open AccessUnglycosylated recombinant human glutathione peroxidase 3 mutant from Escherichia coli is active as a monomer
- Jian Song
- , Yang Yu
- & Hongwei Song
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| Open AccessDefining the membrane disruption mechanism of kalata B1 via coarse-grained molecular dynamics simulations
- Wanapinun Nawae
- , Supa Hannongbua
- & Marasri Ruengjitchatchawalya
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| Open AccessIdentification of Three Novel Mutations in the FRMD7 Gene for X-linked Idiopathic Congenital Nystagmus
- Xiao Zhang
- , Xianglian Ge
- & Feng Gu
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| Open AccessRobust analysis of synthetic label-free DNA junctions in solution by X-ray scattering and molecular simulation
- Kyuhyun Im
- , Daun Jeong
- & Kinam Kim
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| Open AccessSynergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding
- Yoshimi Sato
- , Rieko Kojima
- & Kenji Inaba
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| Open AccessAb Initio structure prediction for Escherichia coli: towards genome-wide protein structure modeling and fold assignment
- Dong Xu
- & Yang Zhang
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| Open AccessInter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2)
- Panpan Hou
- , Wenping Zeng
- & Jiuping Ding
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| Open AccessUV-radiation Induced Disruption of Dry-Cavities in Human γD-crystallin Results in Decreased Stability and Faster Unfolding
- Zhen Xia
- , Zaixing Yang
- & Ruhong Zhou
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| Open AccessIdentification of cardiolipin binding sites on cytochrome c oxidase at the entrance of proton channels
- C. Arnarez
- , S. J. Marrink
- & X. Periole
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| Open AccessAge-dependent α-synuclein aggregation in the Microcebus murinus lemur primate
- Marie-Hélène Canron
- , Martine Perret
- & Benjamin Dehay