Correspondence |
Featured
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News & Views |
50 & 100 years ago
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Editorial |
A framework for success
The time is ripe for Europe's scientists to lobby for community-wide infrastructure funding.
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News & Views |
Face of the past reconstructed
DNA is particularly well preserved in hair — enabling the genome of a human to be sequenced, and his ancestry and appearance to be determined, from 4,000-year-old remains.
- David M. Lambert
- & Leon Huynen
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Article |
Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
To survive and evade host responses, malaria parasites export several hundred proteins into the host cell on infection. A feature of these proteins is a conserved, pentameric motif that is cleaved by an unknown protease before export. This is one of two independent studies revealing the identity of the protease as plasmepsin V, an aspartic acid protease located in the endoplasmic reticulum. This enzyme is essential for parasite viability and is an attractive candidate for drug development.
- Ilaria Russo
- , Shalon Babbitt
- & Daniel E. Goldberg
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Career Brief |
Boost for brain research
Fellowship aims to boost collaborative research at European academic institutions and industrial labs.
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Column |
Better all the time
Innovation policies are more likely to be successful if they leverage existing capabilities, argues Daniel Sarewitz.
- Daniel Sarewitz
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Article |
Retroviral intasome assembly and inhibition of DNA strand transfer
The integrase protein of retroviruses such as HIV-1 catalyses insertion of the viral genome into that of the host. Here, the long-awaited structure of the full-length integrase complex is predicted, revealing not only details of the biochemistry of the integration reaction, but also the means by which current inhibitors affect this process.
- Stephen Hare
- , Saumya Shree Gupta
- & Peter Cherepanov
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Editorial |
Valid concerns
The reporting of candidate biomarkers for disease must be rigorous to drive translational research.
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Editorial |
Learning to share
By opening up its database of potential malaria drugs, GlaxoSmithKline has blazed a path that other pharmaceutical companies should follow.
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News Feature |
Translational research: Talking up translation
Alan Ashworth took a cancer drug from Petri dish to patients in near record speed. Daniel Cressey meets a biologist who is evangelical about translational research.
- Daniel Cressey
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News |
Stem-cell line given the nod
NIH moves to approve cells in limbo after rule change.
- Brendan Borrell
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News |
GlaxoSmithKline goes public with malaria data
Company to place structures and properties of drug leads in the public domain.
- Declan Butler
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Column |
World view: Wild goose chase
Quantitative research assessment is a bad idea whose time has come, argues Colin Macilwain.
- Colin Macilwain
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News |
Israel hails first steps towards funding agency
Weightier grants will provide security for biomedical researchers.
- Haim Watzman
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Editorial |
Call for a bigger vision
Science in Canada cannot realize its full potential without clear direction from government.
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Opinion |
Canada needs a polar policy
A lack of coordination in Arctic research funding leaves scientists without the support they need for fieldwork. John England outlines how Canada can set things right, and show leadership in the north.
- John England
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Editorial |
A decade for psychiatric disorders
There are many ways in which the understanding and treatment of conditions such as schizophrenia are ripe for a revolution.