News & Views |
Featured
-
-
News |
‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission
Engineered immune cells, most commonly used to treat cancers, show their power against lupus and other immune disorders.
- Heidi Ledford
-
Book Review |
The unsung geniuses who uncovered why we sleep and dream
Just 100 years ago, we understood astoundingly little about sleep and dreaming. A tight-knit band of researchers changed things, against sometimes considerable odds.
- Jennifer L. Martin
-
News |
CRISPR 2.0: a new wave of gene editors heads for clinical trials
Landmark approval of the first CRISPR therapy paves the way for treatments based on more efficient and more precise genome editors.
- Heidi Ledford
-
News & Views |
Harmful tumour–kidney interactions identified
Fatal renal dysfunction is often associated with tumour development. Fly and mouse data reveal evolutionarily conserved mechanisms that link tumours to renal failure and offer potential for future therapeutic approaches.
- Pierre Leopold
-
News |
Are your organs ageing well? The blood holds clues
One organ in a person’s body can age faster than the rest — with implications for health and mortality.
- Max Kozlov
-
-
News |
Brain implants help people to recover after severe head injury
Electrodes placed inside the brains of five people with traumatic injuries improved recipients’ performance in attention and memory tests.
- Miryam Naddaf
-
Article |
Genetic risk converges on regulatory networks mediating early type 2 diabetes
Integration of multiomics data with functional analysis of pancreatic tissues from individuals with early-stage type 2 diabetes indicates that the genetic risk converges on RFX6, which regulates chromatin architecture at multiple risk loci.
- John T. Walker
- , Diane C. Saunders
- & Marcela Brissova
-
Comment |
Generative AI could revolutionize health care — but not if control is ceded to big tech
Large language models such as that used by ChatGPT could soon become essential tools for diagnosing and treating patients. To protect people’s privacy and safety, medical professionals, not commercial interests, must drive their development and deployment.
- Augustin Toma
- , Senthujan Senkaiahliyan
- & Bo Wang
-
News Feature |
These volunteers want to be infected with disease to aid research — will their altruism help?
An advocacy group is pushing for more ‘human challenge’ trials to spur vaccine discovery. Following COVID-19 and Zika studies, hepatitis C could be next.
- Ewen Callaway
-
News & Views |
15 years after a giant leap for cancer genomics
In 2008, the first comprehensive sequence of a cancer genome was reported, ushering in a new era of molecular diagnostic, prognostic and therapeutic advances informed by an essential framework to understand cancer’s complexities.
- Sheng F. Cai
- & Ross L. Levine
-
News |
ChatGPT generates fake data set to support scientific hypothesis
Researchers say that the model behind the chatbot fabricated a convincing bogus database, but a forensic examination shows it doesn’t pass for authentic.
- Miryam Naddaf
-
Research Highlight |
Botox’s paralysing effects can relieve an uncontrolled head tremor
A bacterial toxin used to reduce wrinkles can also treat a common disorder in older people.
-
News Explainer |
How wild monkeys ‘laundered’ for science could undermine research
Demand is fuelling an illegal trade. But smuggled monkeys carry diseases that can disrupt experiments and lead to unreliable data.
- Gemma Conroy
-
Article
| Open AccessCD201+ fascia progenitors choreograph injury repair
Spatiotemporal regulation of wound healing in mice and humans occurs via retinoic acid and hypoxia signalling, which regulate the differentiation of CD201+ fibroblast progenitors into proinflammatory and myofibroblast states.
- Donovan Correa-Gallegos
- , Haifeng Ye
- & Yuval Rinkevich
-
Editorial |
Brain and body are more intertwined than we knew
A host of disorders once thought to be nothing to do with the brain are, in fact, tightly coupled to nervous-system activity.
-
News Feature |
The rise of brain-reading technology: what you need to know
As implanted devices and commercial headsets advance, what will the real-world impacts be?
- Liam Drew
-
News |
Cancer trial results show power of weaponized antibodies
Tumour-targeting antibodies coupled with toxic chemicals are an unprecedented success in treating bladder cancer.
- Heidi Ledford
-
Research Briefing |
Identification of neuronal connections between heart and brain that trigger fainting
The neural pathways involved in syncope, or fainting, are not well understood. Studies in mice have identified a defined subset of vagal sensory neurons that connect the heart and brain. Stimulation of these neurons causes reduced heart rate, blood pressure, breathing and neuronal activity in the brain, resulting in syncope.
-
News Feature |
Psychedelic treatments are speeding towards approval — but no one knows how they work
Many questions remain about the formerly taboo chemicals that are being used to treat trauma and depression.
- Sara Reardon
-
Nature Podcast |
A new hydrogel can be directly injected into muscle to help it regenerate
A soft and conductive material shows promise for muscle rehabilitation, and why starfishes have such strange body plans.
- Nick Petrić Howe
- & Shamini Bundell
-
News Explainer |
Is CRISPR safe? Genome editing gets its first FDA scrutiny
Advisers to the US regulatory agency will examine the safety profile of a CRISPR-based treatment for sickle-cell disease.
- Heidi Ledford
-
News Feature |
An AI revolution is brewing in medicine. What will it look like?
Emerging generalist models could overcome some limitations of first-generation machine-learning tools for clinical use.
- Mariana Lenharo
-
Comment |
Long COVID research risks losing momentum – we need a moonshot
Investing US$1 billion every year for the next ten years into long COVID research could improve the lives of millions and save trillions in economic costs.
- Lisa McCorkell
- & Michael J. Peluso
-
Article
| Open AccessThe burden and dynamics of hospital-acquired SARS-CoV-2 in England
Data from acute hospitals in England are used to quantify hospital-acquired SARS-CoV-2 infections, evaluate likely pathways of spread and factors associated with heightened transmission risk, and explore the impact on community transmission.
- Ben S. Cooper
- , Stephanie Evans
- & Gwenan M. Knight
-
Article
| Open AccessClinical trial links oncolytic immunoactivation to survival in glioblastoma
Treatment with the oncolytic herpes virus CAN-3110 is associated with improved survival responses in patients with recurrent glioblastoma, particularly in individuals who are seropositive for HSV1.
- Alexander L. Ling
- , Isaac H. Solomon
- & E. Antonio Chiocca
-
News & Views |
AI rapidly diagnoses brain tumours during surgery
A machine-learning method to assess DNA can accurately classify brain tumours in real time. This rapid analysis might help surgeons to identify the tumour type when operating and to adjust their surgical strategy accordingly.
- Lissa C. Baird
-
News |
New pill helps COVID smell and taste loss fade quickly
The antiviral drug ensitrelvir, which shortens sensory problems, is one of the few COVID-19 drugs available to people not at high risk of grave illness.
- Mariana Lenharo
-
Article
| Open AccessTargeting myeloid chemotaxis to reverse prostate cancer therapy resistance
A translational study demonstrates the role of myeloid inflammatory cells in driving disease progression and treatment resistance in prostate cancer and shows that these cells can be targeted therapeutically.
- Christina Guo
- , Adam Sharp
- & Johann S. de Bono
-
News Explainer |
Anti-obesity drugs’ side effects: what we know so far
Recent studies evaluate risks associated with drugs such as Wegovy and Mounjaro.
- Mariana Lenharo
-
News |
This is the largest map of the human brain ever made
Researchers catalogue more than 3,000 different types of cell in our most complex organ.
- Gemma Conroy
-
News & Views |
Pig-to-primate organ transplants require genetic modifications of donor
A raft of alterations to the pig genome — removing three antigen-encoding genes, adding seven human genes and eliminating a retrovirus — allows kidneys to be transplanted into monkeys, with implications for clinical trials.
- Muhammad M. Mohiuddin
-
News |
Monkey survives for two years after gene-edited pig-kidney transplant
Survival time is one of the longest for any interspecies transplant — and moves pig organs closer to human use.
- Max Kozlov
-
Article
| Open AccessApoptotic stress causes mtDNA release during senescence and drives the SASP
During senescence, minority mitochondrial outer membrane permeabilization leads to the release of mtDNA into the cytosol through BAX and BAK macropores, in turn activating the cGAS–STING pathway, a major regulator of the senescence-associated secretory phenotype.
- Stella Victorelli
- , Hanna Salmonowicz
- & João F. Passos
-
Article
| Open AccessDesign and testing of a humanized porcine donor for xenotransplantation
Using kidneys from a genetically engineered porcine donor transplanted into a cynomolgus monkey model, the design, creation and long-term function of kidney grafts supporting life are explored.
- Ranjith P. Anand
- , Jacob V. Layer
- & Wenning Qin
-
Correspondence |
Collateral damage from accelerated drug approval
- Akihiko Ozaki
- , Kenji Gonda
- & Tetsuya Tanimoto
-
News & Views |
From the archive: science on TV, and the Lancet turns 100
Snippets from Nature’s past.
-
News |
Gene therapies for rare diseases are under threat. Scientists hope to save them
As industry steps aside, scientists seek innovative ways to make sure expensive treatments can reach people who need them.
- Heidi Ledford
-
News Feature |
Why rings of RNA could be the next blockbuster drug
The commercial success of RNA vaccines for COVID-19 has revved up interest in circular RNAs as the next generation of therapies.
- Elie Dolgin
-
Article
| Open AccessThe PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
An orally bioavailable small-molecule active-site inhibitor of the phosphatases PTPN2 and PTPN1, ABBV-CLS-484, demonstrates immunotherapeutic efficacy in mouse models of cancer resistant to PD-1 blockade.
- Christina K. Baumgartner
- , Hakimeh Ebrahimi-Nik
- & Robert T. Manguso
-
Comment |
Why researchers should use human embryo models with caution
Scientists should carefully consider whether embryo models based on human stem cells are essential to their work because of the associated practical and ethical challenges.
- Janet Rossant
- & Jianping Fu
-
Outlook |
RSV treatments are here: now the work begins
Efforts to prevent infections and keep vulnerable people out of hospital are beginning to pay off, but deploying these strategies presents new challenges.
- Benjamin Plackett
-
Outlook |
Antibody therapies set to transform respiratory syncytial virus prevention for babies
Drugs that counter RSV infection can safeguard newborns, offering another mode of protection alongside vaccines.
- Elie Dolgin
-
Outlook |
Research round-up: respiratory syncytial virus
Why monitoring sewers could help to detect outbreaks, how RSV and flu viruses can couple together and other highlights.
- Liam Drew
-
News |
Is depression lifting? AI that interprets brain waves has answers
A pattern of brain activity linked with recovery from severe depression could be used to improve therapies such as deep-brain stimulation
- Max Kozlov
-
Article
| Open AccessCingulate dynamics track depression recovery with deep brain stimulation
This study demonstrates how activity in the cingulate cortex tracks depression recovery, providing symptom relief using deep brain stimulation.
- Sankaraleengam Alagapan
- , Ki Sueng Choi
- & Christopher J. Rozell
-
Article |
A multi-stem cell basis for craniosynostosis and calvarial mineralization
The calvarial stem cell niche is populated by a cathepsin K-expressing cell lineage and a newly identified discoidin domain-containing receptor 2-expressing lineage, both of which are required for proper calvarial mineralization.
- Seoyeon Bok
- , Alisha R. Yallowitz
- & Matthew B. Greenblatt
-
News & Views |
From the archive: harmful insects, and Michael Faraday battles jargon
Snippets from Nature’s past.
-
News |
Super-precise CRISPR tool enters US clinical trials for the first time
Base editing, which makes specific changes to a cell’s genome, is put to the test in CAR-T-cell treatments for leukaemia.
- Heidi Ledford