Featured
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Article |
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
Endogenous formaldehyde accumulation reveals Cockayne syndrome in mice and stimulates production of the anorexiogenic peptide GDF15 in proximal tubule cells.
- Lee Mulderrig
- , Juan I. Garaycoechea
- & Ketan J. Patel
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Article |
De novo NAD+ synthesis enhances mitochondrial function and improves health
Genetic or pharmacological inhibition of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase increases NAD+ and improves mitochondrial function in nematodes and mice, and may have therapeutic potential in kidney and liver disease.
- Elena Katsyuba
- , Adrienne Mottis
- & Johan Auwerx
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Letter |
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells
The molecular mechanism of Goodpasture disease is modelled to mechanistically determine how a human leukocyte antigen (HLA) allele can exert its dominant protective effect in autoimmune disease.
- Joshua D. Ooi
- , Jan Petersen
- & A. Richard Kitching
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Letter |
PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection
PGC1α protects against kidney injury by upregulating enzymes that enhance nicotinamide adenine dinucleotide (NAD) and driving local accumulation of the fatty acid breakdown product β-hydroxybutyrate, which leads to increased production of the renoprotective prostaglandin E2.
- Mei T. Tran
- , Zsuzsanna K. Zsengeller
- & Samir M. Parikh