Featured
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Article |
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer
Defective DNA interstrand crosslink repair in Fanconi anaemia drives extensive genomic rearrangements, thereby substantially increasing the risk of cancer development.
- Andrew L. H. Webster
- , Mathijs A. Sanders
- & Agata Smogorzewska
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Article
| Open AccessEffect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
Spatial profiling and single-cell RNA sequencing are used to map the spatial distribution of the microbiota within human tumours, revealing how intratumoral microbial communities contribute to tumour heterogeneity and cancer progression.
- Jorge Luis Galeano Niño
- , Hanrui Wu
- & Susan Bullman
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Article
| Open AccessMitochondrial RNA modifications shape metabolic plasticity in metastasis
- Sylvain Delaunay
- , Gloria Pascual
- & Michaela Frye
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Article
| Open AccessIntermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs
A study using a mouse solid tumour model suggests that adjusting the dosing frequency of the PI3Kδ inhibitor AMG319 in the treatment of human cancers could decrease tumour growth with fewer adverse effects.
- Simon Eschweiler
- , Ciro Ramírez-Suástegui
- & Christian H. Ottensmeier
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Article |
Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer
An analysis of human papillomavirus (HPV)-specific CD8 T cells in patients with head and neck cancer identifies functional PD-1+TCF-1+CD8 T cells in the tumour with implications for therapeutic vaccination and PD-1 directed immunotherapy.
- Christiane S. Eberhardt
- , Haydn T. Kissick
- & Rafi Ahmed
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Article |
Defining HPV-specific B cell responses in patients with head and neck cancer
Detailed analyses of B cells in the tumour microenvironment of human papilloma virus (HPV)-linked head and neck cancers reveal strong humoral immune responses to HPV antigens and the secretion of HPV-specific antibodies in situ.
- Andreas Wieland
- , Mihir R. Patel
- & Rafi Ahmed
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Letter |
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
H3K36me2 targets DNMT3A to intergenic regions and this process, together with H3K36me3-mediated recruitment of DNMT3B, has a key role in establishing and maintaining genomic DNA methylation landscapes.
- Daniel N. Weinberg
- , Simon Papillon-Cavanagh
- & Chao Lu
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Article
| Open AccessComprehensive genomic characterization of head and neck squamous cell carcinomas
The Cancer Genome Atlas presents an integrative genome-wide analysis of genetic alterations in 279 head and neck squamous cell carcinomas (HNSCCs), which are classified by human papillomavirus (HPV) status; alterations in EGFR, FGFR, PIK3CA and cyclin-dependent kinases are shown to represent candidate targets for therapeutic intervention in most HNSCCs.
- Michael S. Lawrence
- , Carrie Sougnez
- & Wendell G. Yarbrough
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Letter |
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression
CFIm25 is identified as a factor that prevents messenger RNAs being shortened due to altered 3′ polyadenylation, which typically occurs when cells undergo high proliferation and correlates with increased tumorigenic activity in glioblastoma tumours.
- Chioniso P. Masamha
- , Zheng Xia
- & Eric J. Wagner
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Research Highlights |
Weakening tumour defences