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| Open AccessPrinted, Flexible Lactate Sensors: Design Considerations Before Performing On-Body Measurements
- Margaret E. Payne
- , Alla Zamarayeva
- & Ana Claudia Arias
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| Open AccessTrp–His covalent adduct in bilirubin oxidase is crucial for effective bilirubin binding but has a minor role in electron transfer
- Tomáš Kovaľ
- , Leona Švecová
- & Jan Dohnálek
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| Open AccessPhosphorylation of adducin-1 by cyclin-dependent kinase 5 is important for epidermal growth factor-induced cell migration
- Chia-Yi Su
- , Ruei-Liang Yan
- & Hong-Chen Chen
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| Open AccessMechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation
- Christopher T. Lohans
- , Emily I. Freeman
- & Christopher J. Schofield
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| Open AccessStructure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability
- Catarina S. Tomé
- , Raquel R. Lopes
- & João B. Vicente
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| Open AccessThe coral Platygyra verweyi exhibits local adaptation to long-term thermal stress through host-specific physiological and enzymatic response
- Jih-Terng Wang
- , Yi-Ting Wang
- & Chaolun Allen Chen
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Article
| Open AccessDistinct effects of Q925 mutation on intracellular and extracellular Na+ and K+ binding to the Na+, K+-ATPase
- Hang N. Nielsen
- , Kerri Spontarelli
- & Bente Vilsen
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Article
| Open AccessNuclease dead Cas9 is a programmable roadblock for DNA replication
- Kelsey S. Whinn
- , Gurleen Kaur
- & Harshad Ghodke
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| Open AccessEffects of T-2 toxin on digestive enzyme activity, intestinal histopathology and growth in shrimp Litopenaeus vannamei
- Zhanrui Huang
- , Yaling Wang
- & Jian Zhao
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Article
| Open AccessResidues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin
- Leslie A. Pelc
- , Sarah K. Koester
- & Enrico Di Cera
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Article
| Open AccessPeptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy
- Christoph Bock
- , Tina Zollmann
- & Rupert Abele
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Article
| Open AccessStructural basis for broad substrate specificity of UDP-glucose 4-epimerase in the human milk oligosaccharide catabolic pathway of Bifidobacterium longum
- Young-Woo Nam
- , Mamoru Nishimoto
- & Shinya Fushinobu
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Article
| Open AccessCu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H2O2 via cysteine-dependent redox short-circuit
- Shamchal Bakavayev
- , Nimrod Chetrit
- & Stanislav Engel
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| Open AccessMutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose
- David J. Carrier
- , Carlo W. T. van Roermund
- & Alison Baker
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Article
| Open AccessIntrinsic dynamic behavior of enzyme:substrate complexes govern the catalytic action of β-galactosidases across clan GH-A
- Rajender Kumar
- , Bernard Henrissat
- & Pedro M. Coutinho
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Article
| Open AccessMechanism of catalysis and inhibition of Mycobacterium tuberculosis SapM, implications for the development of novel antivirulence drugs
- Paulina Fernandez-Soto
- , Alexander J. E. Bruce
- & Lydia Tabernero
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Article
| Open AccessFunctional Roles of Metabolic Intermediates in Regulating the Human Mitochondrial NAD(P)+-Dependent Malic Enzyme
- Ju-Yi Hsieh
- , Wan-Ting Shih
- & Hui-Chih Hung
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Article
| Open AccessA universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity
- Emily C. Sheppard
- , Sally Rogers
- & Richard Chahwan
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Article
| Open AccessMechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis
- Yuya Kitajima
- , Takuya Ishii
- & Motowo Nakajima
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Article
| Open AccessDegradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations
- Raffaela S. Berger
- , Lisa Ellmann
- & Katja Dettmer
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Article
| Open AccessTransducin activates cGMP phosphodiesterase by trapping inhibitory γ subunit freed reversibly from the catalytic subunit in solution
- Teizo Asano
- , Satoru Kawamura
- & Shuji Tachibanaki
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Article
| Open AccessStructural basis of substrate recognition by a novel thermostable (S)-enantioselective ω-transaminase from Thermomicrobium roseum
- Sunghark Kwon
- , Jun Hyuck Lee
- & Hyun Ho Park
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Article
| Open AccessVitamin K2 cannot substitute Coenzyme Q10 as electron carrier in the mitochondrial respiratory chain of mammalian cells
- Cristina Cerqua
- , Alberto Casarin
- & Eva Trevisson
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Article
| Open AccessATP-binding Cassette Transporters Substantially Reduce Estimates of ALDH-positive Cancer Cells based on Aldefluor and AldeRed588 Assays
- Jin Won Park
- , Kyung-Ho Jung
- & Kyung-Han Lee
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Article
| Open AccessIncreased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer’s Disease Mutant of APP
- Alexander Götz
- , Philipp Högel
- & Dieter Langosch
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| Open AccessContext-dependent activity of A domains in the tyrocidine synthetase
- Anna Degen
- , Florian Mayerthaler
- & Barbara Di Ventura
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Article
| Open AccessStructural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor
- Tibisay Guevara
- , Arturo Rodríguez-Banqueri
- & F. Xavier Gomis-Rüth
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Article
| Open AccessThe DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS
- Mathilde Niocel
- , Romain Appourchaux
- & Andrea Cimarelli
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Article
| Open AccessThe proton pumping bo oxidase from Vitreoscilla
- Simone Graf
- , Peter Brzezinski
- & Christoph von Ballmoos
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Article
| Open AccessEvidence for Escherichia coli DcuD carrier dependent FOF1-ATPase activity during fermentation of glycerol
- L. Karapetyan
- , A. Valle
- & K. Trchounian
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Article
| Open AccessThe ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency
- Noah Manczyk
- , Gianluca Veggiani
- & Frank Sicheri
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Article
| Open AccessATP synthesis at physiological nucleotide concentrations
- Axel Meyrat
- & Christoph von Ballmoos
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Article
| Open AccessStructural basis of small RNA hydrolysis by oligoribonuclease (CpsORN) from Colwellia psychrerythraea strain 34H
- Chang Woo Lee
- , Sun-Ha Park
- & Jun Hyuck Lee
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Article
| Open AccessSubstituting the catalytic proline of 4-oxalocrotonate tautomerase with non-canonical analogues reveals a finely tuned catalytic system
- Michael S. Lukesch
- , Tea Pavkov-Keller
- & Birgit Wiltschi
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Article
| Open AccessIdentification and characterization of a factor Va-binding site on human prothrombin fragment 2
- Alexander P. Friedmann
- , Anatoli Koutychenko
- & Paul Y. Kim
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Article
| Open AccessEnteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation
- Jessica M. Molkentine
- , Tara N. Fujimoto
- & Cullen M. Taniguchi
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| Open AccessBio-cleaning of nitrate salt efflorescence on stone samples using extremophilic bacteria
- Ida Romano
- , Mario Abbate
- & Loredana D’Orazio
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| Open AccessNew insights into the coordination between the polymerization and 3′-5′ exonuclease activities in ϕ29 DNA polymerase
- Alicia del Prado
- , Irene Rodríguez
- & Margarita Salas
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Article
| Open AccessBiochemical and Proteomic Characterization of Recombinant Human α/β Hydrolase Domain 6
- Christina Miyabe Shields
- , Nikolai Zvonok
- & Alexandros Makriyannis
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| Open AccessLocal anaesthetics upregulate nitric oxide generation in cord blood and adult human neutrophils
- Karolina I. Kulinska
- , Maria Billert
- & Hanna Billert
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| Open AccessNovel non-phosphorylative pathway of pentose metabolism from bacteria
- Seiya Watanabe
- , Fumiyasu Fukumori
- & Yasuo Watanabe
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Article
| Open AccessSynthesis and Kinetic evaluation of an azido analogue of methylerythritol phosphate: a Novel Inhibitor of E. coli YgbP/IspD
- Zoljargal Baatarkhuu
- , Philippe Chaignon
- & Myriam Seemann
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| Open AccessThe proton and metal binding sites responsible for the pH-dependent green-red bioluminescence color tuning in firefly luciferases
- Vadim R. Viviani
- , Gabriele V. M. Gabriel
- & P. S. Lopes-de-Oliveira
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Article
| Open AccessIMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis
- Ningyu Zhu
- , Xia Wang
- & Shuyi Si
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| Open AccessIdentification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication
- Timur Rusanov
- , Tatiana Kent
- & Richard T. Pomerantz
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Article
| Open AccessEfficient silica synthesis from tetra(glycerol)orthosilicate with cathepsin- and silicatein-like proteins
- Natalia V. Povarova
- , Nikolay A. Barinov
- & Konstantin A. Lukyanov
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Article
| Open AccessExtensions to Michaelis-Menten Kinetics for Single Parameters
- R. T. K. Ariyawansha
- , B. F. A. Basnayake
- & M. I. M. Mowjood
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Article
| Open AccessOff-axis rotor in Enterococcus hirae V-ATPase visualized by Zernike phase plate single-particle cryo-electron microscopy
- Jun Tsunoda
- , Chihong Song
- & Kazuyoshi Murata
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Article
| Open AccessCrystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis
- Zoran Štefanić
- , Marta Narczyk
- & Marija Luić