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| Open AccessA pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
- Ilir Sheraj
- , N. Tulin Guray
- & Sreeparna Banerjee
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| Open AccessBispecific repurposed medicines targeting the viral and immunological arms of COVID-19
- Martin A. Redhead
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| Open AccessA multiplexed nanostructure-initiator mass spectrometry (NIMS) assay for simultaneously detecting glycosyl hydrolase and lignin modifying enzyme activities
- Nicole Ing
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| Open AccessiTRAQ-mediated analysis of the relationship between proteomic changes and yak longissimus lumborum tenderness over the course of postmortem storage
- Yayuan Yang
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| Open AccessTransition state analogue of MTAP extends lifespan of APCMin/+ mice
- Ross S. Firestone
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- & Vern L. Schramm
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| Open AccessStructural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7
- Akihiro Nakamura
- , Yoshiyuki Suzuki
- & Wataru Ogasawara
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| Open AccessStreptococcus agalactiae amylomaltase offers insight into the transglycosylation mechanism and the molecular basis of thermostability among amylomaltases
- Suthipapun Tumhom
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- & Piamsook Pongsawasdi
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| Open AccessThe influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans
- Christopher J. Esh
- , Bryna C. R. Chrismas
- & Lee Taylor
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| Open AccessSerum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
- Anne-Christine Bay-Jensen
- , Asger Bihlet
- & Morten A. Karsdal
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| Open AccessGraphene oxide assisted light-up aptamer selection against Thioflavin T for label-free detection of microRNA
- Md Mamunul Islam
- , Victoria Michele Ghielmetti
- & Peter B. Allen
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| Open AccessCrystal structures of non-oxidative decarboxylases reveal a new mechanism of action with a catalytic dyad and structural twists
- Matthias Zeug
- , Nebojsa Markovic
- & Jun-yong Choe
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| Open AccessUtilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires
- Sanja Babić
- , Lara Čižmek
- & Polonca Trebše
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| Open AccessMulti-functionality of a tryptophan residue conserved in substrate-binding groove of GH19 chitinases
- Takuya Nagata
- , Shoko Shinya
- & Tamo Fukamizo
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| Open AccessSarcolipin alters SERCA1a interdomain communication by impairing binding of both calcium and ATP
- Cédric Montigny
- , Dong Liang Huang
- & Nadège Jamin
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| Open AccessStructural and biochemical analyses of an aminoglycoside 2′-N-acetyltransferase from Mycolicibacterium smegmatis
- Chang-Sook Jeong
- , Jisub Hwang
- & Jun Hyuck Lee
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| Open AccessConformational gating, dynamics and allostery in human monoacylglycerol lipase
- Sergiy Tyukhtenko
- , Xiaoyu Ma
- & Alexandros Makriyannis
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| Open AccessUncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases
- Benoît Desguin
- , Julian Urdiain-Arraiza
- & Patrice Soumillion
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| Open AccessGeneralized enzymatic mechanism of catalysis by tetrameric l-asparaginases from mesophilic bacteria
- Pawel Strzelczyk
- , Di Zhang
- & Jacek Lubkowski
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| Open AccessAn optimized desuccinylase activity assay reveals a difference in desuccinylation activity between proliferative and differentiated cells
- Taolin Yuan
- , Jaap Keijer
- & Vincent C. J. de Boer
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| Open AccessAutomated AFM analysis of DNA bending reveals initial lesion sensing strategies of DNA glycosylases
- Disha M. Bangalore
- , Hannah S. Heil
- & Ingrid Tessmer
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| Open AccessMechanism for the reactivation of the peroxidase activity of human cyclooxygenases: investigation using phenol as a reducing cosubstrate
- Chengxi Yang
- , Peng Li
- & Bao Ting Zhu
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| Open AccessCystathionine β-synthase is involved in cysteine biosynthesis and H2S generation in Toxoplasma gondii
- Carolina Conter
- , Silvia Fruncillo
- & Alessandra Astegno
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| Open AccessExogenous proline induces regulation in 2-acetyl-1-pyrroline (2-AP) biosynthesis and quality characters in fragrant rice (Oryza sativa L.)
- Haowen Luo
- , Tantan Zhang
- & Xiangru Tang
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| Open AccessMolecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy
- Anna Barile
- , Isabel Nogués
- & Angela Tramonti
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| Open AccessA FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases
- Sven T. Sowa
- , Carlos Vela-Rodríguez
- & Lari Lehtiö
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| Open AccessRole of the activation peptide in the mechanism of protein C activation
- Bosko M. Stojanovski
- , Leslie A. Pelc
- & Enrico Di Cera
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| Open AccessRole of water in cyclooxygenase catalysis and design of anti-inflammatory agents targeting two sites of the enzyme
- Manpreet Kaur
- , Baljit Kaur
- & Palwinder Singh
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| Open AccessSubstrate Channeling via a Transient Protein-Protein Complex: The case of D-Glyceraldehyde-3-Phosphate Dehydrogenase and L-Lactate Dehydrogenase
- Željko M. Svedružić
- , Ivica Odorčić
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| Open AccessResponses of AG1 and AG2 QTL introgression lines and seed pre-treatment on growth and physiological processes during anaerobic germination of rice under flooding
- Satyen Mondal
- , M. Iqbal R. Khan
- & Abdelbagi M. Ismail
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| Open AccessFusing α and β subunits of the fungal fatty acid synthase leads to improved production of fatty acids
- Florian Wernig
- , Sandra Born
- & Mislav Oreb
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| Open AccessAlternative catalytic residues in the active site of Esco acetyltransferases
- Tahereh Ajam
- , Inessa De
- & Gregor Eichele
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| Open AccessStructural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici
- Cancan Yang
- , Jing Li
- & XiuGuo Zhang
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| Open AccessPreservation of hydrogen peroxide-induced oxidative damage in HepG-2 cells by rice protein hydrolysates pretreated with electron beams
- Xinxia Zhang
- , Li Wang
- & Yanan Li
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| Open AccessThe F220C and F45L rhodopsin mutations identified in retinitis pigmentosa patients do not cause pathology in mice
- Tylor R. Lewis
- , Camilla R. Shores
- & Marie E. Burns
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| Open AccessMolecular mechanism of the dual regulatory roles of ATP on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
- Pengkai Sun
- , Tuya Bai
- & Jianping Ding
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| Open AccessA novel method to determine antibiotic sensitivity in Bdellovibrio bacteriovorus reveals a DHFR-dependent natural trimethoprim resistance
- Emanuele Marine
- , David Stephen Milner
- & Klaas Martinus Pos
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| Open AccessMdm2 enhances ligase activity of parkin and facilitates mitophagy
- Seunghyi Kook
- , Xuanzhi Zhan
- & Eugenia V. Gurevich
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| Open AccessX-ray Crystallography and Electron Paramagnetic Resonance Spectroscopy Reveal Active Site Rearrangement of Cold-Adapted Inorganic Pyrophosphatase
- Masaki Horitani
- , Kazuki Kusubayashi
- & Keiichi Watanabe
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| Open AccessPurification, Characterization and Mechanistic Evaluation of Angiotensin Converting Enzyme Inhibitory Peptides Derived from Zizyphus Jujuba Fruit
- Mina Memarpoor-Yazdi
- , Hadi Zare-Zardini
- & Leila Navapour
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| Open AccessInsight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation
- Elie Matta
- , Assel Kiribayeva
- & Alexander A. Ishchenko
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| Open AccessThe endocannabinoid hydrolase FAAH is an allosteric enzyme
- Enrico Dainese
- , Sergio Oddi
- & Mauro Maccarrone
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| Open AccessYqfB protein from Escherichia coli: an atypical amidohydrolase active towards N4-acylcytosine derivatives
- Rūta Stanislauskienė
- , Audrius Laurynėnas
- & Rolandas Meškys
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| Open AccessRadiomodifying action, Pharmacokinetic and Biodistribution of Ethyl 3, 4, 5-trihydroxybenzoate-Implication in development of radiomitigator
- Pranav K Pandey
- , B. Ahmed
- & H. A. Khan
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| Open AccessRole of the I16-D194 ionic interaction in the trypsin fold
- Bosko M. Stojanovski
- , Zhiwei Chen
- & Enrico Di Cera
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| Open AccessEffects of enzymatic browning reaction on the usability of tobacco leaves and identification of components of reaction products
- Yanjie Chen
- , Junfei Zhou
- & Yan Jin
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| Open AccessInsight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase
- Federica Ruggieri
- , Jonatan C. Campillo-Brocal
- & Per Berglund
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| Open AccessMycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells
- A. N. Meza
- , C. C. N. Cambui
- & A. Balan
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| Open AccessADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing
- Roland Imle
- , Bei-Tzu Wang
- & Sven Wolfgang Sauer
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| Open AccessConsecutive Marcus Electron and Proton Transfer in Heme Peroxidase Compound II-Catalysed Oxidation Revealed by Arrhenius Plots
- Audrius Laurynėnas
- , Marius Butkevičius
- & Juozas Kulys