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| Open AccessSafety of traditional Chinese medicine injection based on spontaneous reporting system from 2014 to 2019 in Hubei Province, China
- Rui Huang
- , Yuanxuan Cai
- & Shangfeng Tang
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| Open AccessAdolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood
- Francisco J. Flores-Ramirez
- , Anapaula Themann
- & Sergio D. Iñiguez
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| Open AccessA meta-analysis comparing short-term weight and cardiometabolic changes between olanzapine/samidorphan and olanzapine
- Manit Srisurapanont
- , Sirijit Suttajit
- & Narong Maneeton
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| Open AccessGenotoxic and oxidative effect of duloxetine on mouse brain and liver tissues
- Isela Álvarez-González
- , Scarlett Camacho-Cantera
- & Eduardo Madrigal-Bujaidar
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| Open AccessPerformance of preclinical models in predicting drug-induced liver injury in humans: a systematic review
- Hubert Dirven
- , Gunn E. Vist
- & Katya Tsaioun
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| Open AccessConcomitant drugs associated with increased mortality for MDMA users reported in a drug safety surveillance database
- Isaac V. Cohen
- , Tigran Makunts
- & Kelan Thomas
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| Open AccessNon-specific interactions of antibody-oligonucleotide conjugates with living cells
- Victor Lehot
- , Isabelle Kuhn
- & Alain Wagner
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| Open AccessOlanzapine induced reproductive toxicity in male rats
- Cankız Mina Ardıç
- , Sinem Ilgın
- & Özlem Atlı-Eklioğlu
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| Open AccessMaternal use of sedative drugs and its effects on pregnancy outcomes: a Finnish birth cohort study
- Satu-Maarit Björkstedt
- , Hannu Kautiainen
- & Merja K. Laine
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| Open AccessProton pump inhibitors associated acute kidney injury and chronic kidney disease: data mining of US FDA adverse event reporting system
- Bin Wu
- , Dan Li
- & Yuwen Li
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| Open AccessSafety, biodistribution and viral shedding of oncolytic vaccinia virus TG6002 administered intravenously in healthy beagle dogs
- Jérémy Béguin
- , Murielle Gantzer
- & Philippe Erbs
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| Open AccessEffects of a commercially formulated glyphosate solutions at recommended concentrations on honeybee (Apis mellifera L.) behaviours
- Qi-Hua Luo
- , Jing Gao
- & Qing-Yun Diao
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| Open AccessPrediction of pharmacological activities from chemical structures with graph convolutional neural networks
- Miyuki Sakai
- , Kazuki Nagayasu
- & Shuji Kaneko
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| Open AccessIdentifying side effects of commonly used drugs in the treatment of Covid 19
- İrfan Aygün
- , Mehmet Kaya
- & Reda Alhajj
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| Open AccessEvaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia
- Tomonori Ozaki
- , Tatsuya Kawamoto
- & Noriyuki Tsumaki
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Article
| Open AccessOptimal treatment strategy of fremanezumab in migraine prevention: a systematic review with network meta-analysis of randomized clinical trials
- I-Hsin Huang
- , Po-Chien Wu
- & Yi-No Kang
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Article
| Open AccessThe safety profile of Bald’s eyesalve for the treatment of bacterial infections
- Blessing O. Anonye
- , Valentine Nweke
- & Freya Harrison
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| Open AccessImmortalization of human hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing
- Manami Nishiwaki
- , Masashi Toyoda
- & Akihiro Umezawa
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Article
| Open AccessEvaluation of the safety profile of rotavirus vaccines: a pharmacovigilance analysis on American and European data
- Giulia Bonaldo
- , Roberta Noseda
- & Domenico Motola
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Article
| Open AccessCorrelation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides
- Ines Greco
- , Natalia Molchanova
- & Johan Svenson
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| Open AccessLeflunomide monotherapy versus combination therapy with conventional synthetic disease-modifying antirheumatic drugs for rheumatoid arthritis: a retrospective study
- Daihua Deng
- , Jun Zhou
- & Jing Yang
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| Open AccessRisk of domperidone induced severe ventricular arrhythmia
- Byeong Geun Song
- , Yeong Chan Lee
- & Poong-Lyul Rhee
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| Open AccessThe pharmaceutical solvent N-methyl-2-pyrollidone (NMP) attenuates inflammation through Krüppel-like factor 2 activation to reduce atherogenesis
- Marta Roche-Molina
- , Bryn Hardwick
- & Juan A. Bernal
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| Open AccessTofacitinib treatment aggravates Staphylococcus aureus septic arthritis, but attenuates sepsis and enterotoxin induced shock in mice
- Anders Jarneborn
- , Majd Mohammad
- & Tao Jin
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Article
| Open AccessPredicted effect of ticagrelor on the pharmacokinetics of dabigatran etexilate using physiologically based pharmacokinetic modeling
- Nan Wang
- , Lu Chen
- & Wensheng Liu
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Article
| Open AccessIdentifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient
- Vincent N. Duong
- , Lei Zhou
- & Karen S. Anderson
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| Open AccessDrug response analysis for scaffold-free cardiac constructs fabricated using bio-3D printer
- Kenichi Arai
- , Daiki Murata
- & Koichi Nakayama
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| Open AccessCharacterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart
- Louise M. Hesketh
- , Catherine D. E. Wilder
- & Michael J. Curtis
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| Open AccessIn-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o
- Leonard Blum
- , Sheraz Gul
- & Susanne Schiffmann
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Article
| Open AccessThe Cognitive Effects of Statins are Modified by Age
- Ahmed M. Alsehli
- , Gaia Olivo
- & Helgi B. Schiöth
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| Open AccessCross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells
- James Kramer
- , Herbert M. Himmel
- & Gary Gintant
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Article
| Open AccessBipyrazone: a new HPPD-inhibiting herbicide in wheat
- Hengzhi Wang
- , Weitang Liu
- & Jinxin Wang
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| Open AccessThe cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles
- Sophie Fletcher
- , Helen Maddock
- & Mayel Gharanei
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| Open AccessPresentations, Causes and Outcomes of Drug-Induced Liver Injury in Egypt
- Omkolthoum Alhaddad
- , Maha Elsabaawy
- & Mohsen Salama
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| Open AccessGadolinium labelled nanoliposomes as the platform for MRI theranostics: in vitro safety study in liver cells and macrophages
- Pavlína Šimečková
- , František Hubatka
- & Jaroslav Turánek
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| Open AccessEvaluation of antifungal effect and toxicity of xanthyletin and two bacterial metabolites against Thai isolates of Pythium insidiosum
- Kittiya Wittayapipath
- , Chavi Yenjai
- & Petr Hamal
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| Open AccessDatabase of adverse events associated with drugs and drug combinations
- Aleksandar Poleksic
- & Lei Xie
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| Open AccessComprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolites during seasonal study
- Ticiano Gomes do Nascimento
- , Rodolfo Elleson dos Santos Arruda
- & David George Watson
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| Open Accessβ-Cyclodextrin counteracts obesity in Western diet-fed mice but elicits a nephrotoxic effect
- Angelique M. L. Scantlebery
- , Peter Ochodnicky
- & Sandrine Florquin
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| Open AccessChildhood growth hormone treatment in women with Turner syndrome - benefits and adverse effects
- Tomasz Irzyniec
- , Wacław Jeż
- & Jakub Frelich
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| Open AccessDelving into the Antiurolithiatic Potential of Tribulus terrestris Extract Through –In Vivo Efficacy and Preclinical Safety Investigations in Wistar Rats
- Jyoti Kaushik
- , Simran Tandon
- & Chanderdeep Tandon
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| Open AccessThe Effect of Antiarrhythmic Drugs on the Beat Rate Variability of Human Embryonic and Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
- Julius Niehoff
- , Matthias Matzkies
- & Michael Reppel
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Article
| Open AccessSupport Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II
- Keiji Ogura
- , Tomohiro Sato
- & Teruki Honma
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| Open AccessPrioritizing target-disease associations with novel safety and efficacy scoring methods
- Mario Failli
- , Jussi Paananen
- & Vittorio Fortino
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| Open AccessSafety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults
- Dietrich Conze
- , Charles Brenner
- & Claire L. Kruger
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| Open AccessSafety of low-dose subcutaneous recombinant interleukin-2: systematic review and meta-analysis of randomized controlled trials
- Seyed Hamidreza Mahmoudpour
- , Marius Jankowski
- & Stefano Barco
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| Open AccessMetabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers
- Anne Elfgen
- , Michelle Hupert
- & Dieter Willbold
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| Open AccessToxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease
- Silvio Wuschko
- , Alfred Gugerell
- & Hendrik J. Ankersmit
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| Open AccessScaling in vitro activity of CYP3A7 suggests human fetal livers do not clear retinoic acid entering from maternal circulation
- Ariel R. Topletz
- , Guo Zhong
- & Nina Isoherranen