Featured
-
-
Article
| Open AccessValency based novel quantitative structure property relationship (QSPR) approach for predicting physical properties of polycyclic chemical compounds
- Ali Raza
- , Mishal Ismaeel
- & Fikadu Tesgera Tolasa
-
Article
| Open AccessPharmacokinetic and pharmacodynamic evaluation study of etomidate: a randomized, open-label, 2-period crossover study in healthy Chinese subjects
- Ying Ding
- , Nan-nan Chu
- & Qing He
-
Article
| Open Access1,2,3-triazole and chiral Schiff base hybrids as potential anticancer agents: DFT, molecular docking and ADME studies
- Yonas Belay
- , Alfred Muller
- & Abel K. Oyebamiji
-
Article
| Open AccessA highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model
- Lauren M. Weaver
- , Madeline J. Stewart
- & Chang-Guo Zhan
-
Article
| Open AccessN-benzyl-N-methyldecan-1-amine, derived from garlic, and its derivative alleviate 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice
- Ji Eun Kim
- , Phatcharaporn Budluang
- & Young-Hwa Chung
-
Article
| Open AccessLysine demethylase LSD1 is associated with stemness in EBV-positive B cell lymphoma
- Joo Hyun Kim
- , Chaehwa Park
- & Won Seog Kim
-
Article
| Open AccessEnhancing explainable SARS-CoV-2 vaccine development leveraging bee colony optimised Bi-LSTM, Bi-GRU models and bioinformatic analysis
- Dilber Uzun Ozsahin
- , Zubaida Said Ameen
- & Auwalu Saleh Mubarak
-
Article
| Open AccessDevelopment of a novel AAK1 inhibitor via Kinobeads-based screening
- Akari Yoshida
- , Satomi Ohtsuka
- & Hiroshi Tokumitsu
-
Article
| Open AccessExtracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis
- Guo Chen
- , Xinyuan Li
- & Yuanbin Jiang
-
Article
| Open AccessCeratophyllum demersum the submerged macrophyte from the mining subsidence reservoir Nadrybie Poland as a source of anticancer agents
- Maciej Masłyk
- , Tomasz Lenard
- & Konrad Kubiński
-
Article
| Open AccessIn silico approaches for the identification of potential allergens among hypothetical proteins from Alternaria alternata and its functional annotation
- Rajamanikandan Sundararaj
- , Amala Mathimaran
- & Tsehaye Asmelash
-
Article
| Open Access5-HT_FAsTR: a versatile, label-free, high-throughput, fluorescence-based microplate assay to quantify serotonin transport and release
- Lina Bukowski
- , Markus Emanuel Strøm
- & Steffen Sinning
-
Article
| Open AccessRelationship between prediction accuracy and uncertainty in compound potency prediction using deep neural networks and control models
- Jannik P. Roth
- & Jürgen Bajorath
-
Article
| Open AccessAntiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways
- Rubel Hasan
- , Abdulrahman Alshammari
- & Muhammad Torequl Islam
-
Article
| Open AccessPoint biserial correlation symbiotic organism search nanoengineering based drug delivery for tumor diagnosis
- Garima Shukla
- , Sofia Singh
- & Ben Othman Soufiene
-
Article
| Open AccessUnveiling potential drug targets for hyperparathyroidism through genetic insights via Mendelian randomization and colocalization analyses
- Bohong Chen
- , Lihui Wang
- & Na Hao
-
Article
| Open AccessMulti-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker
- Yanxing Li
- , Wentao Gao
- & Jianjun Li
-
Article
| Open AccessAnti-proliferative and apoptotic effect of cannabinoids on human pancreatic ductal adenocarcinoma xenograft in BALB/c nude mice model
- Trung Quang Le
- , Nuntana Meesiripan
- & Kasem Rattanapinyopituk
-
Article
| Open AccessThe roles of autophagy, ferroptosis and pyroptosis in the anti-ovarian cancer mechanism of harmine and their crosstalk
- Jun Zhu
- , Hong Zhu
- & Jun Gao
-
Article
| Open AccessAesculus hippocastanum extract and the main bioactive constituent β-escin as antivirals agents against coronaviruses, including SARS-CoV-2
- Freddy Armando Peñaranda Figueredo
- , Josefina Vicente
- & Carlos Alberto Bueno
-
Article
| Open AccessThe novel drug candidate S2/IAPinh improves survival in models of pancreatic and ovarian cancer
- Takaomi Hagi
- , Suwanna Vangveravong
- & Dirk Spitzer
-
Article
| Open AccessApplication of 32 factorial design for loratadine-loaded nanosponge in topical gel formulation: comprehensive in-vitro and ex vivo evaluations
- Durgaramani Sivadasan
- , Krishnaraju Venkatesan
- & Sami El Deeb
-
Article
| Open AccessPhytochemical composition and in vitro antioxidant and antimicrobial activities of Bersama abyssinica F. seed extracts
- Belayhun Alemu
- , Meseret Derbew Molla
- & Tadesse Asmamaw
-
Article
| Open AccessComputational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data
- Franziska Meiners
- , Burkhard Hinz
- & Israel Barrantes
-
Article
| Open AccessDevelopment of extended pharmacokinetic models for propofol based on measured blood and brain concentrations
- Masayoshi Kawata
- , Atsushi Yonezawa
- & Yoshiki Arakawa
-
Article
| Open AccessUltra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics
- Delia I. Fernández
- , Sara Troitiño
- & Johan W. M. Heemskerk
-
Article
| Open AccessTargeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia
- Léa Ikhlef
- , May Yassine
- & Paul-François Gallet
-
Article
| Open AccessCharacterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array
- Minami Hiranuma
- , Yuichi Okuda
- & Tomohisa Watanabe
-
Article
| Open AccessDigital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model
- Radina Kostadinova
- , Simon Ströbel
- & Mathieu Petitjean
-
Article
| Open AccessEfficacy of silver nanoparticles against Trichinella spiralis in mice and the role of multivitamin in alleviating its toxicity
- Noha Madbouly Taha
- , Fady Sayed Youssef
- & Reem M. Ramadan
-
Article
| Open AccessDesert date seed extract-loaded chitosan nanoparticles ameliorate hyperglycemia and insulin deficiency through the reduction in oxidative stress and inflammation
- Alyaa Farid
- , Alaa Ahmed
- & Gehan Safwat
-
Article
| Open AccessClassical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation
- Feier Zeng
- , Abbie Wade
- & Aymen I. Idris
-
Article
| Open AccessA high-throughput gut-on-chip platform to study the epithelial responses to enterotoxins
- Moran Morelli
- , Marta Cabezuelo Rodríguez
- & Karla Queiroz
-
Article
| Open AccessPharmacological evaluation and phytochemical profiling of butanol extract of L. edodes with in- silico virtual screening
- Umer Ejaz
- , Muhammad Afzal
- & Abdullah F. Alasmari
-
Article
| Open AccessBioinformatics analysis and experimental validation revealed that Paeoniflorigenone effectively mitigates cerebral ischemic stroke by suppressing oxidative stress and inflammation
- Zhiyan Wu
- & Xingrong Tang
-
Article
| Open AccessEvaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control
- Harish Kumar Shah
- , Vaishnavi Srinivasan
- & Vijesh Sreedhar Kuttiatt
-
Article
| Open AccessSynthesis, anticancer activity, and molecular docking of half-sandwich iron(II) cyclopentadienyl complexes with maleimide and phosphine or phosphite ligands
- Sujoy Das
- , Marcelina Strachanowska
- & Bogna Rudolf
-
Article
| Open AccessThe deleterious effects of sofosbuvir and ribavirin (antiviral drugs against hepatitis C virus) on different body systems in male albino rats regarding reproductive, hematological, biochemical, hepatic, and renal profiles and histopathological changes
- Rana A. Ali
- , Eatemad A. Awadalla
- & Rehab H. Abdel-Aziz
-
Article
| Open AccessEmerging roles of SIRT1 activator, SRT2104, in disease treatment
- Ning Chang
- , Junyang Li
- & Yajun Wang
-
Article
| Open AccessSynthesis and evaluation of coumarin derivatives on antioxidative, tyrosinase inhibitory activities, melanogenesis, and in silico investigations
- Kasemsiri Chandarajoti
- , Jiraporn Kara
- & Luelak Lomlim
-
Article
| Open AccessStructural basis for the recognition of human hemoglobin by the heme-acquisition protein Shr from Streptococcus pyogenes
- Akinobu Senoo
- , Masato Hoshino
- & Kouhei Tsumoto
-
Article
| Open AccessTranscriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells
- Jiraporn Jantaravinid
- , Napatara Tirawanchai
- & Pornanong Aramwit
-
Article
| Open AccessInvestigating the mechanisms underlying resistance to chemoterapy and to CRISPR-Cas9 in cancer cell lines
- Francesca Tomasi
- , Matteo Pozzi
- & Mario Lauria
-
Article
| Open AccessComparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study
- Lawrence Reiter
- , Johann Greffrath
- & Aleksandra Pastrak
-
Article
| Open AccessAiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3
- Sumin Lee
- , Qianying Ye
- & Yong Hwan Park
-
Article
| Open AccessA real-world analysis of FDA Adverse Event Reporting System (FAERS) events for liposomal and conventional doxorubicins
- Huiling Su
- , Jing Jia
- & Zhengjun Li
-
Article
| Open AccessA novel T cell-redirecting anti-GPRC5D × CD3 bispecific antibody with potent antitumor activity in multiple myeloma preclinical models
- Urara Tomita
- , Yoko Ishimoto
- & Toshinori Agatsuma
-
Article
| Open AccessEnhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy
- Carlos A. Lobertti
- , Fernán O. Gizzi
- & Eleonora García Véscovi
-
Article
| Open AccessConjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation
- Mei Ying Ng
- , Zhi Jian Song
- & Thilo Hagen