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RNA-based programmable DNA cleavage
Natural ribozymes can cleave RNA and single-stranded DNA (ssDNA) by transesterification or a blend of hydrolytic and transesterification reactions. Now, ribozymes have been discovered that catalyze the hydrolytic cleavage of ssDNA. Similar ribozymes could potentially replace large, immunogenic, protein-based nucleases in gene therapies.
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Chemical Biology of Microbiomes
Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli
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The β-subunit of tryptophan synthase is a latent tyrosine synthase
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PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein
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Versatility of biological non-heme Fe(II) centers in oxygen activation reactions