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Cryo-electron microscopy structures of cross-exon pre-B and B-like complexes contribute new insights into the molecular mechanisms that mediate the switch from a cross-exon to a cross-intron organized spliceosome.
Prov-GigaPath, a whole-slide pathology foundation model pretrained on a large dataset containing around 1.3 billion pathology images, attains state-of-the-art performance in cancer classification and pathomics tasks.
Atomic-resolution imaging of the surface structure of hexagonal water ice is achieved using cryogenic atomic force microscopy, providing a molecular perspective on the origin and mechanism of of ice premelting.
Single-cell RNA sequencing and 3D imaging have revealed the cellular changes and structural reorganization that occur during the progression of human chronic liver disease and as the liver attempts to regenerate.
Stable chelation of the 147Pm radionuclide in aqueous solution by the newly synthesized organic diglycolamide ligand is demonstrated and the resulting complex studied, showing accelerated shortening of bonds at the beginning of the lanthanide series.
Microballistic impact testing at strain rates greater than 106 s−1 shows that pure metals, including copper, gold and titanium, become stronger with increasing temperature.
We develop a low-temperature, damage-free process using van der Waals lamination to integrate multiple circuit tiers into a monolithic three-dimensional device, incorporating unique multi-tier functionality and resolving legacy issues with the layering technology.
Recovered cement paste can be reclinkered if used as a partial substitute for the lime–dolomite flux used in steel recycling, which can reduce waste and carbon emissions.
An antibody–drug conjugate that targets the pan-haematopoietic marker CD45 combined with transplanted stem cells engineered to be shielded from it can eradicate leukaemic cells while preserving haematopoiesis.
Structures of the kainate receptor GluK2 with and without concanavilin A and BPAM344 show how these ligands modulate channel activity and reveal the molecular basis of kainate receptor gating.
Structural analysis of the human choline and ethanolamine transporters FLVCR1 and FLVCR2 clarifies the mechanisms of transport, the conformational dynamics of these proteins and the disease-associated mutations that interfere with these processes.
Stretchable radio-frequency electronics based on a dielectro-elastic elastomer is demonstrated to be capable of completely maintaining operating frequencies unaffected by strain and shows superior electrical, mechanical and thermal properties compared with conventional stretchable substrate materials.
The adrenal gland of the oldfield mouse (Peromyscus polionotus) has a recently evolved cell type that promotes monogamous-typical parenting behaviour and is not present in closely related species.
We report on a method for inducing uncontaminated and precise inhomogeneous strain in nanoscale silicon ribbons and its use for determining physical effects in these strained materials, in particular, an increase in the range and control of thermal conductivity.
We carried out genomic and ecological analyses of all eight extant baobab species, providing insights into their evolutionary history and recommendations for conservation efforts.