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Experiments in mouse models, and in cell lines that only allow primary Vκ-to-Jκ rearrangements, enable characterization of the mechanisms of V(D)J recombination.
A dual-additive crystallization method using PyNI and 5AVA as additives results in highly efficient 3D perovskite films with enhanced photoluminescence quantum efficiencies and external quantum efficiencies, and hence increased LED performance.
Use of a 20 frames per second (fps) RGB camera plus an event camera can achieve the same latency as a 5,000-fps camera with the bandwidth of a 45-fps camera without compromising accuracy.
In fruit flies, three-dimensional organ arrangement is stereotypical, sexually dimorphic and actively maintained by muscle-vessel mechanochemical crosstalk.
A deep neural network with ‘knockout training’ is used to model sensorimotor transformations and neural perturbations of male Drosophila melanogaster during visually guided social behaviour and provides predictions and insights into relationships between stimuli, neurons and behaviour.
Simple analytic estimates and detailed numerical calculations show that the solar dynamo begins near the surface, rather than at the much-deeper tachocline.
We analyse cell division in ichthyosporeans and find that multinucleated life cycles favour the evolution of closed mitosis, in which the cell constructs a spindle within an intact nucleus.
Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.
Radiopharmaceuticals engineered with click chemistry to selectively bind to tumour-specific proteins can be used to successfully target tumour cells, boosting the pharmacokinetics of radionuclide therapy and improving tumour regression.
The accretion disk from a star tidally disrupted by a supermassive black hole undergoes Lense–Thirring precession with strong, quasi-periodic X-ray flux and temperature modulations.
Experiments using fentanyl treatment of mice show that µ-opioid receptors mediate positive reinforcement in the ventral tegmental area and negative reinforcement in central amygdala, thereby identifying the circuits that lead to opioid addiction.
A study shows that implants with an adhesive implant–tissue interface mitigate the formation of a fibrous capsule when attached to various organs in mice, rats and pigs.
Screening in Escherichia coli and biochemical experiments show that in Arabidopsis thaliana, OSCA2.1 and OSCA2.2 function as plant sensors of hypo-osmolarity, utilize Ca2+ oscillations as second messengers and have crucial roles in pollen germination.
The use of computational crystal-structure prediction has enabled the targeted assembly of frameworks of porous organic ammonium halide salts that have many of the qualities of metal–organic frameworks despite containing no metal.
Time-resolved photoelectron circular dichroism with a temporal resolution of 2.9 fs is used to track the ultrafast electron dynamics following ultraviolet excitation of neutral chiral molecules, which generate chiral currents that exhibit periodic rotation direction reversal.