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Using micropipette aspiration on donated human embryos, cell surface tensions during compaction were mapped, indicating a role for defective cell contractility in poor quality embryos.
Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.
Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.
A study describes chromatin accessibility and paired gene expression across the entire developing human brain during the first trimester in the context of gene regulation and neurodevelopmental disease.
Centimetre-sized single-crystal rhombohedral boron nitride layers are achieved through bevel-edge epitaxy, and the resulting material exhibits robust, homogeneous and switchable ferroelectricity with a high Curie temperature.
Under stressful conditions, mesenchymal stromal cells transfer mitochondria to endothelial cells through tunnelling nanotubes, and artificially transplanting mitochondria into endothelial cells improves the ability of these cells to engraft and to revascularize ischaemic tissues.
Analysis of population decline shows that frequent disturbances enhance a population’s capacity to resist and recover from downturns and that trade-offs exist when adopting new or alternative land-use strategies.
Harnessing single-nucleus RNA sequencing and spatial profiling, this work dissects unanticipated aspects of human liver regeneration to uncover a novel migratory hepatocyte subpopulation mediating wound closure following acute liver injury.
We report on the oxidative cross-coupling of organoboron reagents and amino acids via pyridoxal biocatalysis to produce non-canonical amino acids, uncovering stereoselective, intermolecular free-radical transformations.
A study of male and female rats has examined the biomolecular changes induced in many of their organs by eight weeks of endurance treadmill training. The findings offer insights into the many benefits to our immune, metabolic and stress-response pathways as we adapt to exercise.
By adapting methods for fabricating and testing conventional computer chips, researchers have brought silicon-based quantum computers closer to reality — and to accessing the immense benefits of a mature chipmaking industry.
Researchers deliberately infect participants with SARS-CoV-2 in ‘challenge’ trials — but high levels of immunity complicate efforts to test vaccines and treatments.
Lawmakers interrogated Peter Daszak over his ties to China and whether his organization, EcoHealth Alliance, has been a good steward of taxpayer dollars.
Simple measures to strengthen the interface between science, policy and society in African nations could help the continent leapfrog others in sustainable innovation and development.
Some scientists are reluctant to investigate questions about sex and gender, particularly given today’s sociopolitical tensions around gender identity. But they should lean in and embrace the complexity.