- COMMENT
Opportunities and challenges for innovative and equitable healthcare
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By
- David J. Ecker0,
- Clarice D. Aiello1,
- Joseph R. Arron2,
- C. Frank Bennett3,
- Amy Bernard4,
- Xandra O. Breakefield5,
- Timothy J. Broderick6,
- Shawneequa L. Callier7,
- Barry Canton8,
- Janice S. Chen9,
- C. Simone Fishburn10,
- Banning Garrett11,
- Sidney M. Hecht12,
- Tobias Janowitz13,
- Melinda Kliegman14,
- Adrian Krainer15,
- Chrystal U. Louis16,
- Christopher Lowe17,
- Alfica Sehgal18,
- Yesim Tozan19,
- Kevin J. Tracey20,
- Fyodor Urnov21,
- Daniel Wattendorf22,
- Thomas W. Williams23,
- Xuanhe Zhao24 &
- …
- Michael R. Hayden25
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David J. Ecker
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Ionis Pharmaceuticals, Carlsbad, CA, USA.
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Clarice D. Aiello
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University of California, Los Angeles, Los Angeles, CA, USA.
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Joseph R. Arron
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23andMe Therapeutics, South San Francisco, CA, USA.
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C. Frank Bennett
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Ionis Pharmaceuticals, Carlsbad, CA, USA.
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Amy Bernard
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The Kavli Foundation, Los Angeles, CA, USA.
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Xandra O. Breakefield
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Massachusetts General Brigham & Harvard Medical School, Boston, MA, USA.
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Timothy J. Broderick
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Institute for Human and Machine Cognition, Pensacola, FL, USA.
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Shawneequa L. Callier
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The George Washington University, Washington, DC, USA; Center for Research on Genomics and Global Health, The National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
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Barry Canton
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Ginkgo Bioworks, Boston, MA, USA.
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Janice S. Chen
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Mammoth Biosciences, Brisbane, CA, USA.
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C. Simone Fishburn
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BioCentury, Redwood City, CA, USA.
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Banning Garrett
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Global Federation of Competitiveness Councils, Washington, DC, USA.
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Sidney M. Hecht
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Biodesign Center for BioEnergetics, Arizona State University, Tempe, AZ, USA.
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Tobias Janowitz
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Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
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Melinda Kliegman
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Innovative Genomics Institute, University of California, Berkeley, CA, USA.
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Adrian Krainer
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Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
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Chrystal U. Louis
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Center for Cell and Gene Therapy, Baylor College of Medicine-Texas Children’s Hospital-Houston Methodist Hospital, Houston, TX, USA.
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Christopher Lowe
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University of Cambridge, Cambridge, UK.
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Alfica Sehgal
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CAMP4 Therapeutics, Cambridge, MA, USA.
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Yesim Tozan
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NYU School of Global Public Health, New York, NY, USA.
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Kevin J. Tracey
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The Feinstein Institutes for Medical Research, New York, NY, USA.
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Fyodor Urnov
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Innovative Genomics Institute, University of California, Berkeley, CA, USA.
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Daniel Wattendorf
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Bill & Melinda Gates Foundation, Seattle, WA, USA.
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Thomas W. Williams
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American University, College of Law, Washington, DC, USA.
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Xuanhe Zhao
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Massachusetts Institute of Technology, Boston, MA, USA.
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Michael R. Hayden
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University of British Columbia, Vancouver, British Columbia, Canada.
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Nature Reviews Drug Discovery 23, 321-322 (2024)
doi: https://doi.org/10.1038/d41573-024-00032-4
Acknowledgements
This article includes recommendations of participants in “Future Concepts in Disruptive Therapeutics, 2045”, a conference held at Cold Spring Harbor Laboratory in April 2022.
References
Xie, W., Chen, B. & Wong, J. Genomic medicines: the coming waves? Nat. Rev. Drug Discov. 22, 691–692 (2023).
Doudna, J. A. The promise and challenge of therapeutic genome editing. Nature 578, 229–236 (2020).
Gleeson, J. G. et al. Personalized antisense oligonucleotides ‘for free, for life’ — the n-Lorem Foundation. Nat. Med. 29, 1302–1303 (2023).
Jørgensen, J., Hanna, E. & Kefalas, P. Outcomes-based reimbursement for gene therapies in practice: the experience of recently launched CAR-T cell therapies in major European countries. J. Mark. Access Health Policy 8, 1715536 (2020).
Garrison, L. P. et al. A review of economic issues for gene-targeted therapies: value, affordability, and access. Am. J. Med. Genet. C 193, 64–76 (2023).
Competing Interests
The following authors are employees and shareholders in their affiliated companies: D.J.E., C.F.B., J.R.A., B.C., J.S.C., C.U.L. and A.S. A.R.K. has a financial interest in Stoke Therapeutics. The other authors declare no competing interests.
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